Past Chair

AsPEN Past Chair   1st Frank May  (Australia)   Byung-Joo Park (Korea)       2nd Yea-Huei Yang-Kao (Taiwan)   Kiyoshi Kubota (Japan)       3rd Nicole Pratt (Australia)   Edward Chia-Cheng Lai (Taiwan)       4th Kenneth Man (Hong Kong)       5th      

New AsPEN Office and Secretary

Dear AsPEN members,           Thanks very much for all your effort and support in making the AsPEN sustainable. We would like to show our appreciation to Kiyoshi and NPO DSUR Japan for the management and maintenance of AsPEN office. We specially thank our secretary, Yukari, for her wonderful organization and great assistance to make […]

What is AsPEN

What is AsPEN? The Asian Pharmacoepidemiology Network, or AsPEN, is a multi-national research network which was formed to provide a mechanism to support the conduct of pharmaco-epidemiological research and to facilitate the prompt identification and validation of emerging safety issues among the Asian countries. 1. The History of AsPEN was first suggested at the 3rd […]

“Modified” distributed Network

Modified Distributed Network Model August 2012 We use “modified” distributed network model consisting of the following components: 1) Distributed Network: Raw data are located in the individual site throughout the study and only summary tables will be sent to the coordinating center. 2) Common data structure: Data with the common structure will be prepared by […]

The Prescription Sequence Symmetry Analysis (PSSA) Study 1

The Prescription Sequence Symmetry Analysis (PSSA) Study 1:  Association between antipsychotic use and diabetes. Objective: To test the feasibility of using a distributed model for undertaking studies in AsPEN. Design: A distributed network model was employed using fit for purpose code written by the University of South Australia to test the association between antipsychotic use […]

The Prescription Sequence Symmetry Analysis (PSSA) Study 2

The Prescription Sequence Symmetry Analysis (PSSA) Study 2: Association between thiazolidinediones and cardiovascular diseases. Objective: To test the risk of cardiovascular disease from thiazolidinediones across AsPEN countries. Method: Pharmacogenetic differences between Asian and Caucasian populations led to a hypothesis that the adverse cardiovascular events of thiazolidinediones may be less common in Asian populations than Caucasian […]

The Prescription Sequence Symmetry Analysis (PSSA) Study 3

The Prescription Sequence Symmetry Analysis (PSSA) Study 3: Prescription Symmetry: A validation study Objective: To test the validity of PSSA in identifying one positive and two negative controls across multiple data sets from different countries. Method: The positive control was amiodarone and thyroxine. Amiodarone is known to cause hypothyroidism. The negative controls were 1) amiodarone […]

The Prescription Sequence Symmetry Analysis (PSSA) Study 4

The Prescription Sequence Symmetry Analysis (PSSA) Study 4: Association between proton pump inhibitor use and clostridium difficile infections Objective: To test the risk of treatment for clostridium difficile from proton pump inhibitors across AsPEN countries and Canada. Method: Health Canada had a hypothesis that proton pump inhibitors may contribute to clostridium difficile infections. Australia (two […]

Comparetive Safety of NSAIDs Commonly Used in Asia

Comparative Safety of Nonsteroidal Anti-inflammatory Drugs Commonly Used in Asia Background: Some nonsteroidal anti-inflammatory drugs (NSAIDs) are only or more commonly used in Asian countries (i.e., loxoprofen, mefenamic acid) and their safety has not been well-studied. Objectives: To compare the risk of major safety events among initiators of 4 NSAIDs which are commonly used in […]