Publications
Publications
Peer-reviewed output from AsPEN collaborations. Click a milestone to jump to that year, or use the filters below.
Key milestones
- 2026 · Clinical Pharmacology & Therapeutics
Emulating six cardiovascular outcome trials of antidiabetic drugs using real-world databases from Korea and Taiwan
Ko HY, Au PCM, Cheng MC, Cheung CL, Choi A, Hsieh MH, ..., Shin JY, Park S.
- 2025 · CNS Drugs
International trends in opioid prescribing by age and sex from 2001 to 2019: a population-based study from 18 countries and one special administrative region
Chan AYL, Bahmanyar S, Beyene K, Bushnell G, Carleton B, Chan AHY, ..., Man KKC, Wong ICK.
- 2025 · Communications Medicine
A multinational cohort study of trends in survival following dementia diagnosis
Luo H, Koponen M, Roethlein C, Becker C, Bell JS, Beyene K, ..., Wong GHY, Wong ICK.
- 2025 · Anesthesiology
Global trends in analgesic opioid use in pregnancy
Brett J, Cesta CE, Gillies MB, Bateman BT, Chan AYL, Cheng MC, ..., Man KKC, Zoega H.
- 2025 · Thyroid
Glucagon-like peptide 1 receptor agonists and thyroid cancer risk: an international multisite cohort study
Baxter SM, Lund LC, Andersen JH, Brix TH, Hegedus L, Hsieh MH, ..., Hicks B, Pottegard A.
- 2025 · Journal of the Royal Society of Medicine
The short-, medium- and long-term risk and the multi-organ involvement of clinical sequelae after COVID-19 infection: a multinational network cohort study
Lam ICH, Chai Y, Man KKC, Lau WCY, Luo H, Lin X, ..., Wan EYF, Wong ICK.
- 2025 · BMC Medicine
Psychiatric and neuropsychiatric sequelae of COVID-19 within 2 years: a multinational cohort study
Chai Y, Lam ICH, Man KKC, Hayes JF, Wan EYF, Li X, ..., Wong ICK, Luo H.
- 2025 · EClinicalMedicine
Antiseizure medications consumption in 73 countries and regions from 2012 to 2022: a longitudinal trend study
Chan AYL, Yuen ASC, Hsia Y, Lau WCY, Cross JH, Walker MC, ..., Man KKC, Wong ICK.
antiseizureepilepsydrug utilizationmultinational 📄 Full text DOI: 10.1016/j.eclinm.2025.103558 PMID: 41140454 - 2025 · Diabetes Care
Risk of thyroid tumors with GLP-1 receptor agonists: a retrospective cohort study
Morales DR, Bu F, Viernes B, DuVall SL, Matheny ME, Simon KR, ..., Khera R, Suchard MA.
- 2024 · Nature Medicine
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs
Chan AYL, Gao L, Hsieh MH, Kjerpeseth LJ, Avelar R, Banaschewski T, ..., Man KKC, Wong ICK.
NeuroGENADHDpregnancydiabetesmultinational 📄 Full text DOI: 10.1038/s41591-024-02917-8 PMID: 38589601 - 2024 · JAMA Network Open
Lithium use during pregnancy in 14 countries: a comparative analysis of prescribing patterns
Wittstrom F, Cesta CE, Bateman BT, Bendix M, Bliddal M, Chan AYL, ..., Zoega H, Reutfors J.
lithiumpregnancydrug utilizationmultinational 📄 Full text DOI: 10.1001/jamanetworkopen.2024.51117 PMID: 39680408 - 2024 · The Lancet Psychiatry
Psychotropic drug prescribing before and during the COVID-19 pandemic among people with depressive and anxiety disorders: a multinational network study
Luo H, Chai Y, Li S, Lau WCY, Torre CO, Hayes J, ..., Man KKC, Wong ICK.
psychotropicCOVID 19depressionanxietymultinational 📄 Full text DOI: 10.1016/S2215-0366(24)00245-1 PMID: 39241791 - Infrastructure 2023 · Clinical Epidemiology
Cross-Regional Data Initiative for the Assessment and Development of Treatment for Neurological and Mental Disorders (NeuroGEN)
Detailed description of NeuroGEN's 15-database data infrastructure spanning Asia, Oceania, Europe and North America.
Tsai DHT, Bell JS, Abtahi S, Baak BN, Bazelier MT, Brauer R, ..., Wong ICK, Lai ECC.
NeuroGENdatabasesinfrastructureneurologymental health 📄 Full text DOI: 10.2147/CLEP.S426485 PMID: 38146486 - 2023 · Nature Communications
Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study
Chan AYL, Yuen ASC, Tsai DHT, Lau WCY, Jani YH, Hsia Y, ..., Wong ICK, Man KKC.
gabapentinoiddrug utilizationmultinational 📄 Full text DOI: 10.1038/s41467-023-40637-8 PMID: 37591833 - 2023 · Age and Ageing
Trends of polypharmacy among older people in Asia, Australia and the United Kingdom: a multinational population-based study
Lee H, Baek YH, Kim JH, Liao TC, Lau WCY, Man KKC, ..., Wong ICK, Shin JY.
- 2023 · Journal of Bone and Mineral Research
Global epidemiology of hip fractures: secular trends in incidence rate, post-fracture treatment, and all-cause mortality
Sing CW, Lin TC, Bartholomew S, Bell JS, Bennett C, Beyene K, ..., Cheung CL, Wong ICK.
- 2022 · The Lancet Public Health
Global, regional, and national trends in opioid analgesic consumption from 2015 to 2019: a longitudinal study
Ju C, Wei L, Man KKC, Wang Z, Ma TT, Chan AYL, ..., Wong ICK, Lau WCY.
- 2022 · Eur Child Adolesc Psychiatry
Metabolic events associated with the use of antipsychotics in children, adolescents and young adults: a multinational sequence symmetry study
Man KKC, Shao SC, Chaiyakunapruk N, Dilokthornsakul P, Kubota K, Li J, ..., Kao Yang YH, Lai ECC.
antipsychoticsmetabolicsequence symmetrymultinationalpediatric 📄 Full text DOI: 10.1007/s00787-020-01674-6 PMID: 33185773 - 2022 · Lancet Reg Health West Pac
Monoclonal antibodies and Fc-fusion protein biologic medicines: A multinational cross-sectional investigation of accessibility and affordability in Asia Pacific regions between 2010 and 2020
Tong X, Li X, Pratt NL, Hillen JB, Stanford T, Ward M, ..., Leung WK, Wong ICK.
- 2022 · BioDrugs
Comparative Treatment Persistence with Bone-Targeting Agents Among Asian Patients with Bone Metastases from Solid Tumors: A Multinational Retrospective Cohort Study
Shen CY, Au PC, Baek YH, Cheung CL, Chung WP, Kim JH, ..., Wong ICK, Lai ECC.
- 2021 · The Lancet Psychiatry
Psychotropic medicine consumption in 65 countries and regions, 2008–19: a longitudinal study
Brauer R, Alfageh B, Blais JE, Chan EWY, Chui CSL, Hayes JF, ..., Wei L, Wong ICK.
psychotropicdrug utilizationmultinational 📄 Full text DOI: 10.1016/S2215-0366(21)00292-3 PMID: 34801129 - 2021 · European Journal of Neurology
Global trends in symptomatic medication use against dementia in 66 countries/regions from 2008 to 2018
Ju C, Wong ICK, Lau WCY, Man KKC, Brauer R, Ma TT, ..., Li X, Wei L.
- Infrastructure 2021 · Pharmacoepidemiology and Drug Safety
Suitability of databases in the Asia-Pacific for collaborative monitoring of vaccine safety
Suitability assessment of databases across 19 Asia-Pacific countries for collaborative vaccine-safety monitoring — foundational reference for distributed vaccine surveillance in the region.
Duszynski KM, Stark JH, Cohet C, Huang WT, Shin JY, Lai ECC, ..., Chen RT, Pratt NL.
- 2021 · Epidemiol Psychiatr Sci
Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study
Man KKC, Shao SC, Chang YC, Chi MH, Jeong HE, Lin SJ, ..., Yang YK, Lai ECC.
antipsychoticscardiovascularsccsmultinationalpediatric 📄 Full text DOI: 10.1017/S2045796021000494 PMID: 34751642 - 2021 · Pharmacoepidemiol Drug Saf
Association between methylphenidate and risk of myocardial infarction: A multinational self-controlled case series study
Jeong HE, Lee H, Lai ECC, Liao TC, Man KKC, Wong ICK, Coghill D, Chi MH, Hsieh CY, Shin JY.
- 2021 · BMJ
Use of antipsychotic drugs and cholinesterase inhibitors and risk of falls and fractures: self-controlled case series
Wang GH, Man KKC, Chang WH, Liao TC, Lai ECC.
antipsychoticscholinesterasefallssccsmultinational 📄 Full text DOI: 10.1136/bmj.n1925 PMID: 34503972 - 2021 · Cancers (Basel)
Association between Androgen Deprivation Therapy and Risk of Dementia in Men with Prostate Cancer
Liu JM, Shen CY, Lau WCY, Shao SC, Man KKC, Hsu RJ, Wu CT, Lai ECC.
androgen deprivationprostate cancerdementiamultinational 📄 Full text DOI: 10.3390/cancers13153861 PMID: 34359762 - 2021 · BMJ Open
Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries
Sing CW, Lin TC, Bartholomew S, Bell JS, Bennett C, Beyene K, ..., Zhao H, Wong ICK.
- Infrastructure 2020 · CNS Drugs
Application of Healthcare 'Big Data' in CNS Drug Research: The Example of the Neurological and Mental Health Global Epidemiology Network (NeuroGEN)
Narrative introduction to NeuroGEN — how international 'big data' platforms are applied to CNS drug research.
Ilomaki J, Bell JS, Chan AYL, Tolppanen AM, Luo H, Wei L, ..., Cook S, Wong ICK.
NeuroGENoverviewneurologymental healthmultinational 📄 Full text DOI: 10.1007/s40263-020-00742-4 PMID: 32572794 - 2020 · J Psychiatr Res
Incidence, prevalence and prescription patterns of antipsychotic medications use in Asia and US: A cross-nation comparison with common data model
Su CC, Chia-Cheng Lai E, Kao Yang YH, Man KKC, Kubota K, Stang P, ..., Wong ICK, Setoguchi S.
antipsychoticsdrug utilizationCDMmultinational 📄 Full text DOI: 10.1016/j.jpsychires.2020.08.025 PMID: 32947205 - 2020 · Curr Opin Psychiatry
Using clinical registries, administrative data and electronic medical records to improve medication safety and effectiveness in dementia
Ilomaki J, Lai ECC, Bell JS.
- 2019 · BMJ
Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study
Wei L, Lai ECC, Kao-Yang YH, Walker BR, MacDonald TM, Andrew R.
- 2018 · Clinical Epidemiology
Applying a common data model to Asian databases for multinational pharmacoepidemiologic studies: opportunities and challenges
Lai ECC, Ryan P, Zhang Y, Schuemie M, Hardy NC, Kamijima Y, ..., Yang YH, Setoguchi S.
- 2018 · PLoS One
Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study
Kubota K, Kamijima Y, Kao Yang YH, Kimura S, Chia-Cheng Lai E, Man KKC, ..., Zhang Y, Setoguchi S.
antidiabeticdrug utilizationmultinational 📄 Full text DOI: 10.1371/journal.pone.0208796 PMID: 30540837 - 2018 · Pharmacoepidemiol Drug Saf
Comparative safety of NSAIDs for gastrointestinal events in Asia-Pacific populations: A multi-database, international cohort study
Lai ECC, Shin JY, Kubota K, Man KKC, Park BJ, Pratt N, Roughead EE, Wong ICK, Kao Yang YH, Setoguchi S.
- 2018 · Lancet Psychiatry
Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases
Raman SR, Man KKC, Bahmanyar S, Berard A, Bilder S, Boukhris T, ..., Ip P, Wong ICK.
- 2017 · Eur J Epidemiol
Sequence symmetry analysis in pharmacovigilance and pharmacoepidemiologic studies
Lai ECC, Pratt N, Hsieh CY, Lin SJ, Pottegard A, Roughead EE, Kao Yang YH, Hallas J.
- 2016 · Expert Opin Drug Saf
Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis
Roughead EE, Chan EWY, Choi NK, Griffiths J, Jin XM, Lee J, ..., Yang YK, Pratt NL.
- Infrastructure 2015 · Epidemiology
Databases in the Asia-Pacific Region: the potential for a distributed network approach
Foundational survey of population-level databases across the Asia-Pacific region; primary reference for this site's Databases page.
Lai ECC, Man KKC, Chaiyakunapruk N, Cheng CL, Chien HC, Chui CSL, ..., Zhang Y, Setoguchi S.
- 2015 · Drug Saf
Variation in Association Between Thiazolidinediones and Heart Failure Across Ethnic Groups: Retrospective analysis of Large Healthcare Claims Databases in Six Countries
Roughead EE, Chan EWY, Choi NK, Kimura M, Kimura T, Kubota K, ..., Yang YH, Pratt NL.
thiazolidinedionesheart failuremultinational 📄 Full text DOI: 10.1007/s40264-015-0318-4 PMID: 26216600 - 2015 · Pharmacoepidemiol Drug Saf
Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries
Pratt N, Chan EWY, Choi NK, Kimura M, Kimura T, Kubota K, ..., Kao Yang YH, Roughead EE.
- Infrastructure 2013 · Pharmacoepidemiology and Drug Safety
The Asian Pharmacoepidemiology Network (AsPEN): promoting multi-national collaboration for pharmacoepidemiologic research in Asia
Founding methodology paper of AsPEN — describes the multi-national network and its rapid adverse drug event assessment approach.
Andersen M, Bergman U, Choi NK, Gerhard T, Huang C, Jalbert J, ..., Sundstrom A, Yang YH.
- Infrastructure 2013 · Pharmacoepidemiology and Drug Safety
Multi-country rapid adverse drug event assessment: the Asian Pharmacoepidemiology Network (AsPEN) antipsychotic and acute hyperglycaemia study
First multi-country application of AsPEN's PSSA framework — proof-of-concept for the network's rapid adverse drug event assessment methodology.
Pratt N, Andersen M, Bergman U, Choi NK, Gerhard T, Huang C, ..., Yang YH, Roughead EE.
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