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Infrastructure
The methodological scaffolding every AsPEN study sits on — PSSA, SCCS, target-trial emulation, common data models, and the NeuroGEN platform that now spans 15 databases on four continents.
9 papers · 2013–2023
- Infrastructure 2023 · Clinical Epidemiology
Cross-Regional Data Initiative for the Assessment and Development of Treatment for Neurological and Mental Disorders (NeuroGEN)
Detailed description of NeuroGEN's 15-database data infrastructure spanning Asia, Oceania, Europe and North America.
Tsai DHT, Bell JS, Abtahi S, Baak BN, Bazelier MT, Brauer R, ..., Wong ICK, Lai ECC.
NeuroGENdatabasesinfrastructureneurologymental health 📄 Full text DOI: 10.2147/CLEP.S426485 PMID: 38146486 - Infrastructure 2020 · CNS Drugs
Application of Healthcare 'Big Data' in CNS Drug Research: The Example of the Neurological and Mental Health Global Epidemiology Network (NeuroGEN)
Narrative introduction to NeuroGEN — how international 'big data' platforms are applied to CNS drug research.
Ilomaki J, Bell JS, Chan AYL, Tolppanen AM, Luo H, Wei L, ..., Cook S, Wong ICK.
NeuroGENoverviewneurologymental healthmultinational 📄 Full text DOI: 10.1007/s40263-020-00742-4 PMID: 32572794 - 2020 · Curr Opin Psychiatry
Using clinical registries, administrative data and electronic medical records to improve medication safety and effectiveness in dementia
Ilomaki J, Lai ECC, Bell JS.
- 2018 · Clinical Epidemiology
Applying a common data model to Asian databases for multinational pharmacoepidemiologic studies: opportunities and challenges
Lai ECC, Ryan P, Zhang Y, Schuemie M, Hardy NC, Kamijima Y, ..., Yang YH, Setoguchi S.
- 2017 · Eur J Epidemiol
Sequence symmetry analysis in pharmacovigilance and pharmacoepidemiologic studies
Lai ECC, Pratt N, Hsieh CY, Lin SJ, Pottegard A, Roughead EE, Kao Yang YH, Hallas J.
- Infrastructure 2015 · Epidemiology
Databases in the Asia-Pacific Region: the potential for a distributed network approach
Foundational survey of population-level databases across the Asia-Pacific region; primary reference for this site's Databases page.
Lai ECC, Man KKC, Chaiyakunapruk N, Cheng CL, Chien HC, Chui CSL, ..., Zhang Y, Setoguchi S.
- 2015 · Pharmacoepidemiol Drug Saf
Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries
Pratt N, Chan EWY, Choi NK, Kimura M, Kimura T, Kubota K, ..., Kao Yang YH, Roughead EE.
- Infrastructure 2013 · Pharmacoepidemiology and Drug Safety
The Asian Pharmacoepidemiology Network (AsPEN): promoting multi-national collaboration for pharmacoepidemiologic research in Asia
Founding methodology paper of AsPEN — describes the multi-national network and its rapid adverse drug event assessment approach.
Andersen M, Bergman U, Choi NK, Gerhard T, Huang C, Jalbert J, ..., Sundstrom A, Yang YH.
- Infrastructure 2013 · Pharmacoepidemiology and Drug Safety
Multi-country rapid adverse drug event assessment: the Asian Pharmacoepidemiology Network (AsPEN) antipsychotic and acute hyperglycaemia study
First multi-country application of AsPEN's PSSA framework — proof-of-concept for the network's rapid adverse drug event assessment methodology.
Pratt N, Andersen M, Bergman U, Choi NK, Gerhard T, Huang C, ..., Yang YH, Roughead EE.